Programmable Allosteric DNAzyme Coupled with CRISPR/Cas12a System for Multiplexed and Sensitive Detection of Extracellular Vesicle Derived MicroRNAs
Xiang-Lan He, Le Wang, Cong Zhang, Meng-Meng Pan, Ying Ma, Jia-Qi Du, Ling-Jiao Yang, Ming Wang, Ming Jiang, Li Xu
This paper develops a CRISPR/Cas12a-based system for sensitive and multiplexed detection of EV-derived microRNAs using DNAzyme and machine learning for cancer classification.
bioRxiv · Aug 7, 2026 · PreprintBioengineering