Cross-talk between RNA secondary and three-dimensional structure prediction: a comprehensive study
Deyin Wang, Yangwei Jiang, Linli He, Zhang Linxi, Ruhong Zhou, Dong Zhang
This study benchmarks RNA 3D structure prediction models using varying accuracy 2D structures, finding that 3D models modify input base-pairing interactions and are more sensitive to false positives in 2D structures.
bioRxiv · Jun 23, 2025 · PreprintBiophysics