Somatic mutations reveal the ontogeny of human microglia
Julia A. Belk, Yaowen Zhang, Quanming Shi, Lisa Ma, Raja Sab Kalluru, Alejandro Medina Enciso, Emily E. Reilly, Jacob Weiss, Rui Li, Anna E. Eastman, Nicole L. Womack-Gambrel, Debasmita Paul, Arnav Chakravarthy, Syed Abbas Bukhari, Dipabarna Bhattacharya, , Siddhartha Jaiswal
This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.
bioRxiv · May 20, 2026 · PreprintImmunology