Anne Brunet

Human organoid screen links transient translational modulation to progenitor progression in corticogenesis

The paper screens human cortical organoids with small molecules to identify translational modulators affecting progenitor progression in corticogenesis, finding Emetine promotes neuronal differentiation.

Sexual reproduction impacts vertebrate organ aging

This study shows that lifelong mating in killifish affects liver aging in a sex-specific manner and is associated with younger transcriptomic and proteomic ages in humans.

Somatic mutations reveal the ontogeny of human microglia

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

Engulfment by brain macrophages in a short-lived vertebrate

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

SpatialProp: tissue perturbation modeling with spatially resolved single-cell transcriptomics

SpatialProp predicts the effects of multi-gene perturbations on whole tissue sections using spatially resolved single-cell transcriptomics and graph neural networks.

Life-long behavioral screen reveals an architecture of vertebrate aging

The paper develops a platform for continuous behavioral tracking of vertebrates across their lifespan and identifies distinct aging trajectories linked to transcriptomic changes and predictive models of lifespan.

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

Spatiotemporal transcriptomic profiling and modeling of mouse brain at single-cell resolution reveals cell proximity effects of aging and rejuvenation

The paper develops spatial aging clocks to analyze cell proximity effects in mouse brain aging and rejuvenation, revealing pro-aging and pro-rejuvenating influences of specific cell types.

Plasma proteomics in the UK Biobank reveals youthful brains and immune systems promote healthspan and longevity

The paper uses plasma proteomics from the UK Biobank to estimate organ age and links it to disease risk and longevity.

Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate

This study profiles protein aggregation in seven tissues of aging killifish, revealing tissue-specific patterns linked to protein biophysics and quality control.

Identification of protein aggregates in the aging vertebrate brain with prion-like andphase separation properties

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

Evolution of diapause in the African turquoise killifish by remodeling ancient gene regulatory landscape

This study identifies regulatory innovations in ancient gene programs that drive diapause in the African turquoise killifish, linking chromatin changes to lipid metabolism and survival.

TISSUE: uncertainty-calibrated prediction of single-cell spatial transcriptomics improves downstream analyses

TISSUE improves spatial transcriptomics analysis by providing uncertainty-calibrated predictions, enhancing downstream tasks like clustering and differential expression analysis.

Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem stem cell adhesion and migration during aging

The paper investigates chromatin accessibility changes in neurogenic niche cells during aging, identifying defects in NSC adhesion and migration and proposing ROCK inhibition as a potential therapeutic strategy.

Rapid and precise genome engineering in a naturally short-lived vertebrate

The paper develops a CRISPR/Cas9-mediated knock-in method in African turquoise killifish for precise genomic modifications and cell-type-specific expression.

Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

This study develops cell type-specific aging clocks using single-cell transcriptomic data to quantify aging and rejuvenation in the brain's neurogenic regions.

Males deploy multifaceted strategies and hijack longevity pathways to induce premature demise of the opposite sex

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

CRTC-1 Balances Histone Trimethylation and Acetylation to Promote Longevity

This study identifies CRTC-1's role in balancing histone trimethylation and acetylation to promote longevity in C. elegans.

Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging

This study identifies age-related lipidomic changes in neural stem cells using mass spectrometry and shows that lipid modifications affect NSC function and activation.

In vitro and in vivo CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brain

The paper uses CRISPR-Cas9 screens in vitro and in vivo to identify gene knockouts that enhance neural stem cell activation in aged mice, finding that GLUT4 knockout is a top rejuvenating intervention.

Differentiation drives widespread rewiring of the neural stem cell chaperone network

This study shows that neural stem cell differentiation rewires the chaperone network, reducing TRiC/CCT and increasing sHSPs, which shifts proteostasis strategy and may contribute to neurodegenerative disease susceptibility.

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

This study analyzes epigenomic and transcriptomic changes across mouse tissues with age, identifying age-related immune pathway activation and retroviral sequence upregulation.

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

This study shows that old fibroblasts secrete inflammatory cytokines, leading to variability in reprogramming efficiency and affecting wound healing in older individuals.

Loss of CaMKI function disrupts salt aversive learning in C. elegans

The paper shows that CMK-1 in ASE neurons is essential for salt aversive learning in C. elegans by regulating calcium responses to salt.

Chromatin accessibility dynamics reveal novel functional enhancers in C. elegans

This study uses ATAC-seq in C. elegans to identify dynamic chromatin accessibility changes, revealing novel enhancers and a regulatory factor involved in development.