The role of muscle fascia in heterotopic ossification and maintenance of skeletal muscle integrity in fibrodysplasia ossificans progressiva
L. Russell Hanson, Katherine L. Scalise, Rayna M. Esch, Liv Nevo, David J. Goldhamer
This study shows that fascial injury, not direct muscle injury, induces heterotopic ossification in FOP by activating Acvr1R206H-expressing fibro-adipogenic progenitors, leading to muscle destruction and impaired regeneration.
Bone · Feb 9, 2026Peer-reviewedPathology