Transgene-free hematopoietic stem and progenitor cells from human induced pluripotent stem cells
Laurence Guyonneau-Harmand, Bruno L’Homme, Brigitte Birebent, Christophe Desterke, Nathalie Chevallier, Loïc Garçon, Hélène Lapillonne, Marc Benderitter, François Delhommeau, Thierry Jaffredo, Alain Chapel, Luc Douay
This paper describes a transgene-free protocol to generate hematopoietic stem and progenitor cells (HSPCs) from human induced pluripotent stem cells (hiPSCs), showing their ability to produce myeloid, lymphoid, and red blood cells in vivo.
bioRxiv · Aug 21, 2017 · PreprintCell Biology