Integrated single-cell and spatial transcriptomic analysis of T cell exhaustion and immunometabolic remodeling in HPV-positive oropharyngeal squamous cell carcinoma
Ke Wang, Nian Hui Deng, Yueqin Tao, Xin Yang, Mujie Yuan, Longhua Gao, Shuai Jiang, Wei Shang, Jing Deng, Lin Wang
This study integrates single-cell and spatial transcriptomics to uncover mechanisms of immune checkpoint resistance in HPV-positive oropharyngeal cancer, identifying a KMT2D-KLF7-PD-L1 axis as a therapeutic target.
bioRxiv · Mar 14, 2026 · PreprintCancer Biology