Cancer BiologybioRxivPreprint
Integrated single-cell and spatial transcriptomic analysis of T cell exhaustion and immunometabolic remodeling in HPV-positive oropharyngeal squamous cell carcinoma
Ke Wang, Nian Hui Deng, Yueqin Tao…·Lin Wang
This study integrates single-cell and spatial transcriptomics to uncover mechanisms of immune checkpoint resistance in HPV-positive oropharyngeal cancer, identifying a KMT2D-KLF7-PD-L1 axis as a therapeutic target.