Generative inverse design steers human hematopoietic cell fate in vitro
Licyel Paulas-Condori, Alessandro Palma, Lorenzo Consoli, Juan A. Rubio-Lara, Olivia Hidajat, Weizhong Zheng, Dominik Klein, Deborah G. Martinuzzi, Zhimeng Wu, Andrea Dittadi, Nicola K. Wilson, Berthold Göttgens, Fabian Joachim Theis
This paper introduces LabCompass, a generative inverse-modeling framework that optimizes culture conditions to steer human hematopoietic cell fate in vitro, demonstrating its effectiveness through iterative experimental validation.
bioRxiv · Oct 9, 2026 · PreprintCell Biology