Juan A. Rubio-Lara

This study develops an in vitro clonal competition model to identify preleukemic TET2-mutant clones that suppress wild-type cells through RAC1-GEF signalling inhibition.

This paper introduces LabCompass, a generative inverse-modeling framework that optimizes culture conditions to steer human hematopoietic cell fate in vitro, demonstrating its effectiveness through iterative experimental validation.

This study develops a polymer-based culture system to expand human haematopoietic stem and progenitor cells while preserving age-related transcriptional programs, enabling research on ageing haematopoiesis.