Intense oocyte competition builds the female reproductive reserve in mice
Yan Zhang, Yingnan Bo, Kaixin Cheng, Lu Mu, Jing Liang, Lingyu Li, Xindi C. Hu, Ge Wang, Kaiying Geng, Xuebing Yang, Wenji Wang, Longzhong Jia, Xueqiang Xu, Jingmei Hu, Chao Wang, , Hua Zhang
The paper uses live imaging and single-cell sequencing to show that oocyte competition in mice enhances quality through autophagy-driven debris absorption, essential for fertility.
bioRxiv · Jan 30, 2025 · PreprintDevelopmental Biology