APP binds to the EGFR ligands HB-EGF and EGF, acting synergistically with EGF to promote ERK signaling and neuritogenesis
Joana Fernandes da Rocha, Luísa Bastos, Sara C. Domingues, Ana Rita Bento, Uwe Konietzko, Odete A. B. da Cruz e Silva, Sandra Isabel Vieira
This study identifies HB-EGF and EGF as novel APP interactors and shows their synergistic role in promoting ERK signaling and neuritogenesis.
Molecular Neurobiology · Oct 2, 2020Peer-reviewedNeuroscience