Functional coupling between the a4 - a5 loop and allosteric site on MKP5 is a critical determinant of catalysis
R. Manjula, Lubna Ghanem, Erin Skeens, Leanna Bai, George P. Lisi, Elias Lolis, Anton M. Bennett
The paper investigates how structural changes in the 4-5 loop of MKP5 affect its catalytic activity and shows that mutations in this loop and adjacent regions disrupt enzyme function.
bioRxiv · Jun 2, 2026 · PreprintBiochemistry