Biocatalytic Tetrapeptide Macrocyclization by Cryptic Penicillin-binding Protein-type Thioesterases
Paisley L. Jeannette, Zachary L. Budimir, Lucas O. Johnson, Elizabeth I. Parkinson
This paper discovers a thioesterase enzyme, WP516, capable of efficiently cyclizing a wide range of tetrapeptides, expanding the scope of biocatalytic methods for cyclic tetrapeptide synthesis.
Biochemistry · Jan 29, 2026Peer-reviewedBiochemistry