Elizabeth I. Parkinson

Tertiary structure of a Nif11-like leader peptide mediates protein-protein interactions with a RiPP biosynthetic enzyme

The paper reports the solution structure of a Nif11-LP leader peptide and shows how its tertiary structure mediates protein-protein interactions with a RiPP biosynthetic enzyme.

Streptomyces Autoregulator Biosensors from Natural Product Cluster-Situated Regulators

This paper develops eight CSR-based AR biosensors and their ligands, demonstrating their activation, affinity, selectivity, and potential for orthogonal signaling in bacterial coculturing.

DAP-seq Reveals Cluster-Situated Regulator Control of Numerous Streptomyces Natural Product Biosynthetic Genes

The paper uses DAP-seq to identify CSR regulators of NP biosynthetic genes in Streptomyces, revealing their broad regulatory impact and overlap in BGC control.

Biocatalytic Tetrapeptide Macrocyclization by Cryptic Penicillin-binding Protein-type Thioesterases

This paper discovers a thioesterase enzyme, WP516, capable of efficiently cyclizing a wide range of tetrapeptides, expanding the scope of biocatalytic methods for cyclic tetrapeptide synthesis.

Discovery of cyclic peptide natural product inhibitors of Balamuthia mandrillaris

This study evaluates cyclic peptides as inhibitors of Balamuthia mandrillaris, finding eight compounds with IC50 <5 μM and minimal cytotoxicity.

Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG

The paper identifies D2HG and L2HG-induced O-2-hydroxyglutarylation with chiral specificity, revealing inhibitory effects on kinases MRCKA and SLK.

A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data

The paper introduces two tools, BiG-SCAPE and CORASON, for analyzing biosynthetic gene clusters in large genomic datasets, demonstrating their utility through validation and discovery of new gene cluster families.