Autonomous MTOR activation in COPD airway epithelium impairs resolution through persistent mucus cell metaplasia and lysosome dysfunction
Katrina M. Kudrna, Luis F. Vilches, Wang Xiaoxiao, Jay Wang, Thomas Hugo, Kristina L. Bailey, John D. Dickinson
This study shows that autonomous MTOR activation in COPD airway epithelial cells impairs lysosome function and contributes to persistent mucus cell metaplasia.
bioRxiv · Sep 22, 2026 · PreprintPathology