An interpretable omnigenic neural network architecture for the human genome
Julius Upmeier zu Belzen, Lucas Arnoldt, Noah Hollmann, Luis Herrmann, Khue M. Nguyen, Leonard Eckhoff, Leonhard Kohleick, Sedra Abou Ghaloun, Hannah Schmidt, Stefan Hegselmann, Fabian Joachim Theis, Thore Buergel, Jakob Steinfeldt, Benjamin Wild, Roland Eils
The paper introduces an interpretable neural network architecture for genomic prediction, outperforming existing methods in disease risk prediction and capturing non-linear genetic interactions.
medRxiv · Jul 31, 2026 · PreprintGenetic & Genomic Medicine