Author

Lukas S. Schaffer

University of Colorado Boulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Andrew David GrotzingeriD· 3 shared Jeremy M LawrenceiD· 3 shared Sophie BreunigiD· 3 shared Isabelle Francesca FooteiD· 2 shared Arjun KrishnaniD· 1 shared Elizabeth W. KarlsoniD· 1 shared Michael G. LeviniD· 1 shared Penn Medicine BioBank· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Andrew David GrotzingerORCID

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3 papers

Recent·Most cited

Shared Genetic Liability across Systems of Psychiatric and Physical Illness

Jeremy M Lawrence, Isabelle Francesca Foote, Sophie Breunig, Lukas S. Schaffer, Siraj J. Lyons, Sarah A. Abramowitz, Michael G. Levin, Scott M. Damrauer, Penn Medicine BioBank, Travis T. Mallard, Andrew David Grotzinger

This study uses genomic structural equation modeling to identify genetic overlaps between psychiatric and physical illnesses, finding shared risk factors across multiple domains.

Nature Communications · Feb 21, 2026Peer-reviewedGenetic & Genomic Medicine

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

Sophie Breunig, Young A Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M Lawrence, Lukas S. Schaffer, Andrew David Grotzinger

This study identifies genetic links between clusters of immune-mediated diseases and psychiatric disorders using genomic structural equation modeling and a new heterogeneity metric.

Translational Psychiatry · Jul 21, 2025Peer-reviewedGenetic & Genomic Medicine

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis

Lukas S. Schaffer, Sophie Breunig, Jeremy M Lawrence, Isabelle Francesca Foote, Andrew David Grotzinger

This study identifies genetic pathways unique to autism spectrum disorder (ASD) using Genomic SEM and related methods, finding unique gene expression patterns and genetic correlations with cognitive and psychiatric traits.

Molecular Autism · Oct 15, 2024Peer-reviewedGenetic & Genomic Medicine