Isabelle Francesca Foote

Shared Genetic Liability across Systems of Psychiatric and Physical Illness

This study uses genomic structural equation modeling to identify genetic overlaps between psychiatric and physical illnesses, finding shared risk factors across multiple domains.

The contribution of Apoliproprotein E genetic variation to dementia risk in British South Asians

This study assesses the association between APOE genetic variants and dementia risk in British South Asians using healthcare records and genotyping data.

Domains of Frailty as Early Risk Factors for Alzheimer's Disease -- Genetic and Causal Evidence

This study identifies distinct frailty domains with varying causal relationships to Alzheimer's disease using genetic methods.

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis

This study identifies genetic pathways unique to autism spectrum disorder (ASD) using Genomic SEM and related methods, finding unique gene expression patterns and genetic correlations with cognitive and psychiatric traits.

Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes

This study uses Genomic SEM to analyze genetic differences between bipolar I and II subtypes, finding distinct genetic overlaps with internalizing traits and major depression.

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data

The paper describes a virtual hackathon event that brought together early career scientists to develop tools for Parkinson's disease research using open science principles.