Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving slingshot protein phosphatase 1b enrichment.
Phillip H Kalaniopio, Luke B Gibbons, Ronald S Allen, Saoirse M. Matthews, Oscar R. Lujan, Elyes Gaaloul, Cailyn M Allen, Justin Wilbanks, Connor Chassman, Tinna Traustadóttir, Catherine R. Propper, Matthew C. Salanga
bioRxiv · Jul 8, 2026 · PreprintPharmacology & Toxicology