PathologyAtherosclerosisPeer-reviewed
Hemin-driven chromatin remodelling by atherosclerotic risk gene SMARCA4 switches human blood-derived macrophages from leukocyte disposal to erythrocyte disposal
Luke Cave, Katharine M. Lodge, Derick Chiappo…·Joseph Boyle
This study shows SMARCA4 drives hemin-induced chromatin changes in macrophages, switching their phagocytic target from leukocytes to erythrocytes, contributing to atherosclerosis.
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