Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia
Peggy Rentsch, Jessica Irving, Illya Conn, Kathryn J. Laloli, Luke T. Milham, Sandy Stayte, Bryce Vissel
This study uses PSD95 reporter mice to show D1 and D2 MSN synapse loss in PD and LID, identifies microglia-mediated synapse removal, and suggests microglial depletion as a therapeutic target for dyskinesia.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience