Author

Luyao Ruan

Ontario Institute for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 1

Frequent Co-Authors

Blythe Durbin-Johnson· 2 shared David M RockeiD· 2 shared J. Jared Gossett· 2 shared Sharon Aviran· 2 shared Anni Laine· 1 shared Bhagwan YadaviD· 1 shared Evgeny KulesskiyiD· 1 shared Garry L. CorthalsiD· 1 shared

Activity by Year

2015-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Blythe Durbin-Johnson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rules for PP2A-controlled phosphosignalling and drug responses

Otto Kauko, Susumu Y. Imanishi, Evgeny Kulesskiy, Teemu D. Laajala, Laxman Yetukuri, Anni Laine, Mikael Jumppanen, Pekka Haapaniemi, Luyao Ruan, Bhagwan Yadav, Veronika Suni, Taru Varila, Garry L. Corthals, Jüri Reimand, Krister Wennerberg, , Jukka K. Westermarck

The paper presents a systemic analysis of PP2A-regulated phosphosignaling and drug responses, revealing rules for phosphoregulation and cancer therapy classification.

bioRxiv · Feb 26, 2018 · PreprintSystems Biology

Excess False Positive Rates in Methods for Differential Gene Expression Analysis using RNA-Seq Data

David M Rocke, Luyao Ruan, Yilun Zhang, J. Jared Gossett, Blythe Durbin-Johnson, Sharon Aviran

The paper evaluates differential gene expression methods using RNA-Seq data and finds that methods relying on negative binomial models show high false positive rates, while variance-based methods do not.

bioRxiv · Jun 11, 2015 · PreprintBioinformatics

Controlling False Positive Rates in Methods for Differential Gene Expression Analysis using RNA-Seq Data

David M Rocke, Luyao Ruan, J. Jared Gossett, Blythe Durbin-Johnson, Sharon Aviran

The paper evaluates differential gene expression methods using RNA-Seq data, finding that many produce false positives and recommends limma-voom and simple methods for better performance.

bioRxiv · Apr 30, 2015 · PreprintBioinformatics