Excess False Positive Rates in Methods for Differential Gene Expression Analysis using RNA-Seq Data
David M Rocke, Luyao Ruan, Yilun Zhang, J. Jared Gossett, Blythe Durbin-Johnson, Sharon Aviran
The paper evaluates differential gene expression methods using RNA-Seq data and finds that methods relying on negative binomial models show high false positive rates, while variance-based methods do not.
bioRxiv · Jun 11, 2015 · PreprintBioinformatics