CryoEM reveals how the small molecule EGCG binds to AD brain-derived tau fibrils and initiates fibril disaggregation
P. M. Seidler, D. R. Boyer, M. R. Sawaya, P. Ge, A. Shin, M. A. DeTure, D. W. Dickson, L. Jiang, D. S. Eisenberg
This study uses cryoEM to determine how EGCG binds to AD tau fibrils and initiates their disaggregation by wedging into a cleft and causing charge repulsions.
bioRxiv · May 29, 2020 · PreprintBiochemistry