Origin and evolution of the Zinc Finger Antiviral Protein
D. Goncalves Carneiro, M. A. Takata, H. Ong, A. Shilton, P. D. D. Bieniasz
This paper traces the molecular evolution of ZAP, showing its origin from an ancestral gene and its adaptation to target viral RNA through CpG specificity and co-factor TRIM25 dependence.
bioRxiv · Dec 4, 2020Microbiology