A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transition.
M. Cocco, M. A. Care, M. Al-Maskari, G. M. Doody, R. Tooze
This study identifies a dichotomy in the association of core transcription factors with gene regulation during the activated B-cell to plasmablast transition, showing IRF4 and XBP1 drive ASC gene expression while BLIMP1 represses ABC genes.
bioRxiv · Dec 23, 2019 · PreprintImmunology