CAR T cells for solid tumors: genome-wide dysfunction signature confirms value of c-Jun overexpression, but signals heterogeneity
The paper analyzes scRNA-seq data of JUN CAR T cells in solid tumors using a genome-wide dysfunction signature to show reduced dysfunction but heterogeneity, suggesting potential for improved CAR T cell therapy.
bioRxiv · Feb 7, 2020 · PreprintImmunology