Vasopressin V2 receptor phosphopeptide reshapes the conformational landscape of arrestin-2 beyond C-tail detachment
M. Bzowka, R. Feser, S. Aureli, L. A. Abiko, Francesco Luigi Gervasio
The paper uses simulations to show that V2Rpp binding broadens the conformational landscape of arrestin-2 beyond C-tail detachment, with interdomain rotation angles being less favored without V2Rpp.
bioRxiv · Nov 9, 2026 · PreprintBiochemistry