Author

S. Aureli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. L. Gervasio· 3 shared A. Radoux-Mergault· 1 shared A. Vaithia· 1 shared B. Khanppnavar· 1 shared D. Schuster· 1 shared L. Oberhauser· 1 shared M. Stoeber· 1 shared N. Ansari· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

F. L. Gervasio

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis of connexin-36 gap junction channel inhibition

X. Ding, S. Aureli, A. Vaithia, P. Lavriha, D. Schuster, B. Khanppnavar, X. Li, T. B. Blum, P. Picotti, F. L. Gervasio, V. M. Korkhov

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

bioRxiv · Dec 9, 2023Biophysics

OneOPES, a combined enhanced sampling method to rule them all

V. Rizzi, S. Aureli, N. Ansari, F. L. Gervasio

The paper introduces OneOPES, a replica exchange method combining multi-replica simulations and CV-based enhanced sampling to improve phase space sampling in molecular dynamics.

bioRxiv · Mar 6, 2023Biophysics

Conformational plasticity and allosteric communication networks govern Shelterin protein TPP1 binding to human telomerase

S. Aureli, S. Raniolo, V. Limongelli

This study characterizes the structural properties of TPP1's OB-domain and reveals how conformational plasticity and allosteric communication networks affect TPP1-TERT binding, with implications for disease and therapeutic design.

bioRxiv · Feb 2, 2023 · PreprintBiochemistry

Subcellular location defines GPCR signal transduction

A. Radoux-Mergault, L. Oberhauser, S. Aureli, F. L. Gervasio, M. Stoeber

The paper investigates how subcellular location affects GPCR signaling, showing that opioid receptors in the Golgi and plasma membrane trigger distinct downstream effects.

bioRxiv · Dec 12, 2022Cell Biology