LRET-derived HADDOCK structural models describe the conformational heterogeneity required for processivity of the Mre11-Rad50 DNA damage repair complex
The paper uses LRET and HADDOCK to identify three ATP-bound conformations of the Mre11-Rad50 complex, supported by mutagenesis and SAXS data, suggesting a mechanism for its processivity.
bioRxiv · Aug 4, 2021Biophysics