Fuzzy Supertertiary Interactions within PSD-95 Enable Ligand Binding
M. E. Bowen, H. Sanabria, F. Ding, C. A. Seidel, Y. Hao, C. Zhang, j. Kubiak, F. Wu, F. S. Welcome, S. Basak, N. Saikia, G. L. Hamilton
This study uses molecular dynamics and FRET to analyze PSD-95's conformational dynamics and shows how its flexible structure enables ligand binding.
bioRxiv · Feb 23, 2022Biophysics