Benzoate-Tolerant Escherichia coli Strains from Experimental Evolution Lose the Gad Regulon, Multi-Drug Efflux Pumps, and Hydrogenases
J. P. Moore, H. Li, M. L. Engmann, K. M. Bischof, K. S. Kunka, M. E. Harris, A. C. Tancredi, F. S. Ditmars, P. J. Basting, N. S. George, A. A. Bhagwat, J. L. Slonczewski
This study shows that benzoate-tolerant E. coli strains lose MDR efflux pumps, hydrogenases, and the Gad regulon while upregulating porins, leading to increased antibiotic sensitivity.
bioRxiv · Apr 27, 2019Microbiology