RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity
N. Koralewska, A. Szczepanska, K. Ciechanowska, M. Wojnicka, M. Pokornowska, M. C. Milewski, D. Gudanis, D. Baranowski, C. Nithin, J. M. Bujnicki, Z. Gdaniec, M. Figlerowicz, A. Kurzynska-Kokorniak
This study shows that RNA and DNA G-quadruplexes bind to human Dicer and inhibit its activity by sequestering the Platform-PAZ-Connector helix cassette.
bioRxiv · May 5, 2020Biochemistry