Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones
M. G. Hirsch, Soumitra Pal, Farid Rashidi Mehrabadi, Salem Malikic, Charli Gruen, Antonella Sassano, Eva Pérez-Guijarro, Glenn Merlino, Cenk Sahinalp, Erin K. Molloy, Chi-Ping Day, Teresa M. Przytycka
The paper models gene expression adaptation in tumor subclones using stochastic processes and finds non-genetic mechanisms drive subclonal evolution and treatment response.
bioRxiv · Apr 17, 2024 · PreprintCancer Biology