Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage
A. M. Liaci, B. Steigenberger, S. Tamara, P. C. Telles de Souza, M. Grollers-Mulderij, P. Ogrissek, S.-J. Marrink, R. A. Scheltema, F. Foerster
The paper determines the atomic structures of human signal peptidase complex paralogs and identifies how their architecture enables specific recognition and cleavage of signal peptides.
bioRxiv · Nov 11, 2020Biochemistry