An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA
H. E. R. Baughman, D. Narang, W. Chen, A. C. V. Suarez, J. Lee, M. J. Bachochin, T. R. Gunther, P. G. Wolynes, E. A. Komives
This study shows that the RelA TAD increases NFκB-DNA binding affinity but reduces specificity for κB sequences by enhancing non-specific DNA binding.
bioRxiv · Apr 11, 2022Biochemistry