Author

E. A. Komives

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Silletti· 4 shared W. Chen· 2 shared A. A. Bobkov· 1 shared A. C. V. Suarez· 1 shared A. L. Cooksy· 1 shared A. Medrano-Soto· 1 shared A. P. McGrath· 1 shared B. Bibel· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiochemistry

S. Silletti

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Author profile →

7 papers

Recent·Most cited

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

M. Mealka, N. A. Sierra, D. A. Matteo, E. Albekioni, R. Khoury, T. Mai, B. M. Conley, N. J. Coleman, K. A. Sabo, E. A. Komives, A. A. Bobkov, A. L. Cooksy, S. Silletti, J. M. Schiffer, T. Huxford, C. D. Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

bioRxiv · Jan 10, 2024Biochemistry

An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA

H. E. R. Baughman, D. Narang, W. Chen, A. C. V. Suarez, J. Lee, M. J. Bachochin, T. R. Gunther, P. G. Wolynes, E. A. Komives

This study shows that the RelA TAD increases NFκB-DNA binding affinity but reduces specificity for κB sequences by enhancing non-specific DNA binding.

bioRxiv · Apr 11, 2022Biochemistry

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

B. Bibel, E. Elkayam, S. Silletti, E. A. Komives, L. Joshua-Tor

The paper shows that miRNA-loaded Ago2 binding to target RNA primes its EI for CK1-mediated phosphorylation, which facilitates target release through electrostatic effects.

bioRxiv · Jan 6, 2022Biochemistry

Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

W. Chen, W. Liu, P. Wolynes, E. A. Komives

This study uses single-molecule FRET to show that NF-κB exhibits a continuum of binding modes that control its association and dissociation from DNA, with IκB modulating these dynamics.

bioRxiv · Mar 2, 2021Biophysics

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

S. H. Schmidt, J.-H. Weng, P. C. Aoto, D. Boassa, S. Mathea, S. Silletti, J. Hu, M. Wallbott, E. A. Komives, S. Knapp, F. W. Herberg, S. S. Taylor

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

bioRxiv · Jul 13, 2020Biochemistry

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaH

P. Galaz-Davison, J. A. Molina, S. Silletti, E. A. Komives, S. H. Knauer, I. Artsimovitch, C. A. Ramirez-Sarmiento

This study investigates the structural dynamics of RfaH, a bacterial virulence factor, revealing how differential local stability governs its metamorphic fold-switch between autoinhibited and active states.

Biophysical Journal · Jan 1, 2020Peer-reviewedBiophysics

Cryo-EM Structure of OSCA1.2 from Oryza sativa: Mechanical basis of hyperosmolality-gating in Plants

K. Maity, J. Heumann, A. P. McGrath, N. J. Kopcho, P.-K. Hsu, C.-W. Lee, J. H. Mapes, D. Garza, S. Krishnan, G. P. Morgan, A. Medrano-Soto, K. J. Hendargo, T. Klose, S. D. Rees, M. H. Saier, , M. H. B. Stowell

The paper reports the cryo-EM structure of OsOSCA1.2 from rice, revealing its mechanism for sensing hyperosmolality and mediating ion permeability through structural dynamics.

bioRxiv · Dec 30, 2018Biophysics