Exaptation of two ancient immune proteins into a new dimeric pore-forming toxin in snails
M. L. Giglio, S. Ituarte, V. Milesi, M. S. Dreon, T. R. Brola, J. J. Caramelo, J. C. H. Ip, S. Mate, J.-W. Qiu, L. H. Otero, H. Heras
This paper presents the structure of PmPV2, a MACPF toxin from snail eggs, showing it forms pores in target membranes through a novel dimeric mechanism.
bioRxiv · Dec 23, 2019Biochemistry