PhysiologybioRxiv
The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2
M. M. B. Hoekstra, M. Jan, Y. Emmenegger, P. Franken
This study shows that sleep-wake patterns influence PER2 rhythms in peripheral tissues, with mathematical modeling supporting a dual-force mechanism involving sleep-wake and SCN-independent circadian inputs.
DOI 10.7554/elife.69773