The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting
K. L. Dunlevy, V. Medvedeva, J. E. Wilson, M. Hoque, T. Pellegrin, A. Maynard, M. M. Kremp, J. S. Wasserman, A. Poleshko, R. A. Katz
This study identifies a modular nuclear lamina binding domain in PRR14 that mediates heterochromatin anchoring and is regulated by phosphorylation and a PP2A phosphatase site.
bioRxiv · Oct 8, 2019Cell Biology