Emergent collective organization of bone cells in complex curvature fields
S. J. P. Callens, D. Fan, I. A. J. van Hengel, M. Minneboo, L. E. Fratila-Apachitei, A. A. Zadpoor
This study shows micro-engineered substrates with curvature variations induce collective spatiotemporal organization of preosteoblasts, revealing curvature-guided cell behavior and mechanical regulation.
bioRxiv · Oct 28, 2020Bioengineering