Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling
X. Feng, R. Sun, M. Lee, X. Chen, S. Guo, H. Geng, M. Müschen, J. Choi, J. P. Pereira
The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.
bioRxiv · Sep 23, 2022Immunology