Identification and characterization of zebrafish Tlr4 co-receptor Md-2
A. N. Loes, M. N. Hinman, D. R. Farnsworth, A. C. Miller, K. Guillemin, M. J. Harms
The paper identifies a zebrafish Md-2 homolog, ly96, and shows it forms a Tlr4a complex that activates NF-κB in response to LPS, suggesting an ancestral Tlr4/Md-2 system in vertebrates.
bioRxiv · Oct 24, 2019 · PreprintImmunology