PhysiologybioRxiv
Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease
E. Saponara, C. Penno, M. L. Matadamas Guzman…·H. Ruffner
This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.
DOI 10.1016/j.ajpath.2022.10.008