Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates
J. N. Wells, V. Leber, L. V. Edwardes, S. Allyjaun, M. Peach, J. Tomkins, A. Kefala-Stavridi, S. V. Faull, R. Aramayo, C. M. Pestana, L. Ranjha, C. Speck
This study reconstitutes human DNA licensing, analyzes its intermediates, and identifies how cancer mutations disrupt helicase loading.
bioRxiv · Apr 11, 2024Biochemistry