Testicular Dysgenesis Syndrome-like morphology and gene expression, and activation of Hypoxia Inducible Factor 1 Alpha in juvenile lamb testes following developmental exposure to low-level environmental chemical mixture.
C. S. Elcombe, A. Monteiro, M. R. Elcombe, M. Ghasemzadeh-Hasankolaei, N. P. Evans, M. Bellingham
This study shows that gestational exposure to a chemical mixture in sheep leads to testicular abnormalities and gene expression changes similar to human testicular dysgenesis syndrome.
bioRxiv · Feb 8, 2022Pharmacology & Toxicology