PathologybioRxiv
Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
M. R. Gosselin, V. Mournetas, M. Borczyk…·D. C. Gorecki
This study shows that loss of full-length dystrophin in myoblasts causes cell-autonomous defects in gene expression, proliferation, chemotaxis, and differentiation, contributing to muscle regeneration failure in Duchenne muscular dystrophy.