Pharmacodynamic model of PARP1 inhibition and global sensitivity analyses can lead to cancer biomarker discovery
Susan D. Mertins, Natalie M. Isenberg, Kristofer G. Reyes, Byung-Jun Yoon, Nathan M. Urban, Manasi P. Jogalekar, Morgan E. Diolaiti, M. Ryan Weil, Eric A. Stahlberg
The paper develops an ODE model of PARP1 inhibition, identifies key parameters through sensitivity analysis, and discovers GSPT2 as a biomarker linked to cancer patient outcomes.
bioRxiv · Feb 8, 2023 · PreprintBioinformatics