Precisely control mitochondria with light to manipulate cell fate decision
P. Ernst, N. Xu, J. Qu, H. Chen, M. S. Goldberg, J. Zhang, B. O'Rourke, X. Liu, L. Zhou
This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.
bioRxiv · Nov 13, 2018Biophysics